Best Supplements for PCOS Hormone Balance

  • Mila Magnani
  • 27th October 2025
  • 13 min read
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If you live with PCOS, you know how unpredictable your body can feel. Energy one day, exhaustion the next. Mood swings that seem to come from nowhere. Hair you’re sure you got rid of yesterday.

It’s normal to feel frustrated. Many women, worldwide, felt the same before starting their journey with supplements for PCOS hormone balance. Women that now feel steadier, lighter, and able to talk about their hormones with care, not confusion. 

Science shows the right nutrients can meaningfully support your mood, energy, and metabolism. In this guide, we’ll share what that science — and our experience — says about bringing your balance back.

What Causes Hormone Imbalance in PCOS?

You don’t have PCOS because one hormone is acting up,  it’s a ripple effect across several systems in your body.

One common factor is insulin. When insulin levels rise, they can trigger an increase in testosterone, which disrupts ovulation and mood. Irregular periods, fatigue, and skin changes are familiar signs, with inflammation adding another layer, influencing how your body processes energy and recovers. To find the best supplements for your body, it’s important to consider these root causes. The right nutrients work by supporting underlying pathways, helping your body restore rhythm from within.

When you understand how each factor connects, it’s easier to choose supplements that support hormone harmony.

Do Supplements Really Balance PCOS Hormones? 

Yes. Certain natural supplements for PCOS can support hormone balance by helping your body manage insulin, inflammation, and stress. Nutrients like inositol, zinc, and vitamin B6 work with your body’s natural rhythm, promoting steadier energy, mood, and cycles. They’re not an overnight fix, but a consistent way to help you feel back at home in your body.

How Supplements Can Help You Heal

Supplements aren’t a cure but they can make a real difference. Nutrients work with your body, helping to balance insulin response, reduce inflammation, ease stress, and improve absorption. 

The key to regaining your natural balance lies in consistency and quality. Below, we’ll look at some of the most studied nutrients shown to support hormone balance, and how each one can help you rewrite your own hormonal health story.

Top Supplements for PCOS 

These are the top nutrients to look for, and how each works with your body to bring you closer to hormone harmony. 

Inositol for PCOS Hormone Balance

Inositol is one of the best-studied and most trusted supplements for PCOS hormone balance. This naturally occurring compound helps the body use insulin more effectively. 

Research suggests that a 40:1 ratio of Myo-Inositol to D-Chiro Inositol mirrors the balance found in the body, promoting regular menstrual cycles and supporting fertility.

Hormone Balance follows this same 40:1 ratio — a combination chosen for its strong research base and ability to work gently, not forcefully, with your hormones.

Zinc for PCOS Skin and Hormones

If you think that your skin reflects your hormones, you’re not imagining it, and you’re not alone. Zinc plays a quiet but powerful role in both — supporting clear skin, balanced mood, and healthy cycles. 

For women with PCOS, zinc helps regulate sebum (oil) production and calm inflammation, making it helpful if you’re tired of breakouts.

This powerful nutrient also supports insulin metabolism and ovulation, two systems that often fall out of rhythm with PCOS. Studies suggest that zinc can help lower free testosterone levels and promote regular cycles, too. 

Milamend uses Zinc Picolinate, a form chosen for its gentle absorption and high bioavailability — ensuring your body can actually use what it receives. 

Vitamins for PCOS Fertility

When your cycle feels unpredictable, it’s easy to wonder what’s going on. And sometimes, your body is just missing the nutrients that keep things steady.

Two of the most important are Folate and Vitamin B6, both found in our recipe. Together, they support hormone balance and fertility, in different but connected ways.

Folate helps your cells grow and repair, supporting healthy egg development. 

Vitamin B6 plays a key role in mood, energy, and the production of progesterone (the hormone that helps your cycle stay regular).

Low levels of either are common in PCOS, and topping them up can help bring your body back to balance. Milamend uses bioactive Folate (5-MTHF) and Vitamin B6 (P5P) — forms the body can absorb and use immediately.

Supplements to Regulate Periods (PCOS)

When your period feels unpredictable — late one month, early the next — it’s more than an inconvenience. It’s your body’s way of asking for balance.

Two nutrients shown to help restore that rhythm are Chromium Picolinate and Selenium

Chromium supports healthy insulin function, which plays a major role in regulating ovulation and menstrual cycles. 

Selenium, an antioxidant mineral, supports thyroid health, another system closely tied to cycle regularity.

Research shows that when these nutrients are combined with Inositol, your cycles can become more consistent over time.

Including both Chromium and Selenium, Milamend helps your body return to its natural rhythm — not by forcing change, but by restoring calm.

Natural Supplements for PCOS Hormone Balance

Natural supplements for PCOS don’t work by masking symptoms. They work by supporting the deeper systems within, that influence how you feel. 

What we’ve covered above are just a few of the nutrients inside our delicious blend, Hormone Balance. Each of our ingredients has been carefully selected, tested, and backed by research, because we’re obsessed with quality.

Close-up of light yellow powder with a textured surface

Choosing the Right Supplements for You

All bodies are different, and so is every path to feeling better. 

One thing the experts agree on: your body responds best to gentle, consistent support when it comes to supplements for PCOS hormone balance

It’s important to consider that every brand will promise you balance, but not every blend delivers it. The right supplement for you might not be what’s trending on TikTok.

Here are some key things to look out for:

  • Purity: Ingredients should be clearly listed, free from unnecessary fillers, and sourced from trusted suppliers.
  • Research-backed Ingredients: Look for nutrients supported by published research — not buzzwords.
  • Testing & Transparency: Choose brands that show results, and explain ingredient choices.
  • Consistency: Supplements take time to work. Real change comes from steady, daily support, not overnight promises.

Common Questions

What are the best supplements for PCOS and weight loss?

The most effective are those that help your body work with its natural rhythm. Nutrients like Inositol, Chromium, and Alpha Lipoic Acid support healthy insulin function and metabolism — key factors in managing weight.

Are natural supplements for PCOS safer than prescription options?

“Natural” doesn’t mean risk-free, but high-quality, research-backed supplements can support your body safely. The key is choosing brands that prioritize purity, testing, and transparency. If you’re unsure about starting any new supplement plan, speak with a healthcare provider. 

Our Approach to Hormone Balance

Milamend is a delicious balancing drink created by Mila, our founder, to turn frustration into empowerment, and confusion into calm.

What started as a complicated and expensive supplement routine has become a community built on simplicity, science, and support.

Our blend combines the research-backed nutrients listed above (and many more), chosen to work with your body, not against it. 

Balance shouldn’t be another battle. It should be something every woman can reach, safely, affordably, and with the science to back it up.

Key Takeaways

  • Hormone balance is about patience, consistency, and care.
  • Nutrients like Inositol, Zinc, Folate, Chromium, and Selenium can help support hormone balance by working with your body’s natural rhythm.
  • Quality matters. Your body deserves nutrients that are pure, potent, and backed by science.
  • You can work with your hormones, not against them — and you don’t have to do it alone.

Thousands of women are already finding their balance with Milamend — based on science, made with care. Start today.

Author photo

About the Author

Mila Magnani, Founder of Milamend

References

  • Legro, R. S., et al. (2013). Diagnosis and treatment of polycystic ovary syndrome: An Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology & Metabolism, 98(12), 4565–4592. https://pubmed.ncbi.nlm.nih.gov/24151290 
  • Teede, H. J., et al. (2018). Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertility and Sterility, 110(3), 364–379. https://pubmed.ncbi.nlm.nih.gov/30033227/ 
  • Fitz, V., et al. (2024). Inositol for polycystic ovary syndrome: A systematic review and meta-analysis to inform the 2023 update of the international evidence-based PCOS guidelines. Journal of Clinical Endocrinology & Metabolism, 109(6), 1630–1655. https://pubmed.ncbi.nlm.nih.gov/38163998/ 
  • Swardfager, W., et al. (2013). Zinc in depression: A meta-analysis. Biological Psychiatry, 74(12), 872–878. https://pubmed.ncbi.nlm.nih.gov/23806573/ 
  • Arthur, J. R., Nicol, F., & Beckett, G. J. (1992). The role of selenium in thyroid hormone metabolism and effects of selenium deficiency on thyroid hormone and iodine metabolism. Biological Trace Element Research, 33, 37–42. https://pubmed.ncbi.nlm.nih.gov/1379458/ 
  • Kendall, K. E., & Schnurr, P. P. (1987). The effects of vitamin B6 supplementation on premenstrual symptoms. Obstetrics & Gynecology, 70(2), 145–149. https://pubmed.ncbi.nlm.nih.gov/3299182/ 
  • Zhao, L., et al. (2024). Serum levels of folate, vitamin B6 and vitamin B12 are associated with cognitive impairments in depression patients. Acta Neuropsychiatrica, 36(1), 44–50. https://pubmed.ncbi.nlm.nih.gov/37642170/ 
  • Rajkhowa, M., et al. (1994). Insulin sensitivity in women with polycystic ovary syndrome: Relationship to hyperandrogenaemia. Fertility and Sterility, 61(4), 605–612. https://pubmed.ncbi.nlm.nih.gov/8150099/ 
  • Unfer, V., et al. (2017). Updates on the myo-inositol plus D-chiro-inositol combined therapy in polycystic ovary syndrome. European Review for Medical and Pharmacological Sciences, 21(2), 429–436. https://pubmed.ncbi.nlm.nih.gov/24898153/ 
  • Mehrabani, S., et al. (2019). Effect of coenzyme Q10 supplementation on fatigue: A systematic review of interventional studies. Complementary Therapies in Medicine, 43, 181–187. https://pubmed.ncbi.nlm.nih.gov/30935528/